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| A Good Dam Fight (Silver) | Defeat the Battlelord on the Hoover Dam |
| Air-Duke (Silver) | Win air hockey with a score of 7-0 in the strip club |
| Annihilation (Bronze) | Kill 100 aliens |
| Balls of Steel (Silver) | Earn a 1,000,000 pinball score in SP |
| Baron von Nukem (Bronze) | Shoot down 20 alien fighters |
| Beating the One-Eyed Worm (Silver) | Defeat the Leech |
| Big Guns, Big Ships (Bronze) | Blow up 5 enemy Gunships or Dropships |
| Bucket Head (Bronze) | Find all 3 helmets in the SP campaign |
| Call Waiting (Silver) | Listen to all phone messages |
| Come Get Some (Gold) | Complete the SP campaign on Hard Difficulty |
| Companion Barrel (Bronze) | Unlock the secret closet at the end of the Forkstop |
| Damn, I'm Good (Gold) | Complete the SP campaign on Insane Difficulty |
| Dead Useful (Bronze) | Kill 10 aliens with environmental explosives |
| Drawrings (Bronze) | Doodle something on the whiteboard in SP |
| Duke Angry, Duke SmasH! (Bronze) | Kill 15 aliens with melee attacks while on steroids |
| Extermination (Bronze) | Kill 50 aliens |
| Flagon of Chuckles (Bronze) | Drink a beer in SP |
| Fork the Pork (Bronze) | Kill 6 aliens with the forklift |
| Freeze Well! (Bronze) | Kill 15 frozen aliens |
| Full Body Tourettes (Bronze) | Get knocked down 10 times |
| Gunslinger (Silver) | Carry the gold pistol through the whole SP campaign |
| He's Got a Hologram! (Bronze) | Use a Holoduke in SP |
| Hippy-Stomper (Bronze) | Foot stomp 12 aliens |
| I Am All That Is Man (Silver) | Discover all ego cap rewards |
| I Need a Date (Bronze) | Look at every page of a calender in SP |
| I Need a Towel (Bronze) | Get hit by 10 Pregnator bombs |
| Judge, Jury, Executioner (Bronze) | Execute 20 aliens |
| Juiced (Bronze) | Take steroids in SP |
| Let's Rock (Silver) | Complete the SP campaign on Normal Difficulty |
| Lots of Whacking (Bronze) | Win a game of Alien Abortion in the strip club |
| Natural Disaster 3x (Bronze) | Kill 3 aliens at once |
| Nobody Likes a Whiner (Bronze) | Knock out the talent at the talk show |
| Noms (Bronze) | Eat 10 pieces of food in SP |
| Not Bad for a Human (Silver) | Defeat the Alien Queen |
| Nuclear Devastation (Bronze) | Kill 250 aliens |
| Octacide (Silver) | Defeat the Octaking |
| On the Noggin' (Bronze) | Kill 30 aliens with headshots |
| One-Eyed Freak (Bronze) | Defeat the Cycloid |
| Party Animal (Bronze) | Drink all of the beers in the strip club |
| Pescaphobe (Bronze) | Kill all of the catfish in the underwater level |
| Piece of Cake (Bronze) | Complete the SP campaign on Easy Difficulty |
| Pit Champion (Bronze) | Defeat the Battlelord in Las Vegas |
| Road Rage (Bronze) | Kill 15 aliens with the monster truck |
| Savior of the Universe (Platinum) | You got them all |
| Special Thanks (Bronze) | Watch the credits all the way through |
| Sticky Bomb Like You! (Bronze) | Put a Trip Mine on a live alien |
| Substance Abuser (Bronze) | Drink beer while on steroids or vice-versa in SP |
| Sunday, Black Sunday (Bronze) | Shoot down the blimp above the stadium |
| Tosser...in the Literal Sense (Bronze) | Kill 10 aliens with tossed objects |
| Trapper (Bronze) | Kill 10 aliens with Trip Mines |
| Turd Burglar (Bronze) | Find and steal a piece of poo |
